Excellent 9.1/10
Fast and discreet delivery
Delivery method Cost
Free standard delivery
We dispatch orders from Monday to Friday. If placed before 4pm, your order will be dispatched the same day. Orders placed after 4pm will be sent the next working day.
Next Day Click & Collect
Collect your order from any Royal Mail post office. You will receive an email or SMS when your order is ready for collection. It will be available to collect for up to 18 days. Proof of Identification will be required.
Next Day Express Delivery
If placed before 4pm, your order will be delivered by 1pm on the next working day. Orders placed after 4pm will sent out the next day and delivered the day after.
+ £3.99
Saturday delivery
If placed before 4pm, your order will be delivered by 1pm on Saturday.
+ £7.99

You will choose your delivery option at the checkout. Delivery options
may vary depending on the pack size and dosage chosen.

Circadin is a medication used to treat jet lag. It contains a hormone called melatonin, which regulates the sleep-wake cycle, or “body-clock”.

Order melatonin tablets from DrEd and enjoy your holidays without suffering from jet lag. To place an order, you need to fill in a short medical questionnaire and select your preferred treatment. Our online doctor will review your answers and approve appropriate treatment. Once approved, your medication is dispatched without delay. Orders placed before 4pm will be processed the same day.

10 tablets 24.99
20 tablets 34.99

Prices include prescription and delivery.

What is melatonin?

Circadin contains the active ingredient melatonin, a hormone which naturally occurs in the human body. Depending on the time of the day, your blood levels of melatonin vary. The hormone forms part of your “body clock” and determines at which time you feel awake and and which time you feel tired. Your body increases the production of melatonin when it gets dark, which is why you begin to feel increasingly sleepy as the evening progresses.

When you take a long-distance flight, you cross time zones. As a result, the cycle of day and night that you are used to is interrupted. It will get dark at a different time at your destination, which can be difficult to adjust to. Your body needs to get used to the new time zone and produce melatonin at a different time to allow you to sleep at night. In order to help your body get used to the new routine, you can take Circadin. You need to take a melatonin tablet in the evening before you want to sleep. The melatonin in the tablets will help you sleep when it is night at your travel destination. This way, your body clock will get used to the new time zone quickly.

Melatonin is currently not licensed for use in jet lag in the UK. It is licensed for use to treat insomnia, but a large scientific review has approved its use for prevention of jet lag.

How are the tablets taken?

You need to take one Circadin tablet 1 - 2 hours before you go to bed. Take the tablet after a meal with a glass of water. Swallow the tablet whole without crushing or chewing it. When you order Circadin prolonged-release tablets from DrEd, you will receive a packet of 10 tablets. You should take one on the first night in your new destination, just before bedtime. You can also take a tablet in the same way for the next 2-3 days if needed, until you feel that you have adjusted to the new time zone. (You may also want to repeat this process after your flight home again).

Do not take more than one tablet per day. If you have forgotten one dose, continue your treatment with one tablet the following evening - do not double the dose to make up for the one you have missed.

Each Circadin tablet contains 2mg of the active ingredient melatonin. You can stop taking your melatonin tablets whenever you feel you have adjusted to the new time zone. The medication does not cause any withdrawal symptoms or problems with sleeping.


In addition to 2mg melatonin, Circadin contains ammonio methacrylate copolymer type B, calcium hydrogen phosphate, dihydrate, lactose monohydrate, silica (colloidal anhydrous), talc and magnesium stearate.

Side Effects

Circadin causes side effects in some patients. Seek medical help immediately if you encounter the following side effects:

  • chest pain
  • depression
  • palpitations
  • visual disturbances
  • dizziness or a spinning sensation
  • feeling disoriented
  • blood cells in your urine
  • increased bleeding or bruising
  • changes in your blood levels of certain cells (may show in blood tests)
  • psoriasis (a skin rash)

Most people tolerate Circadin well. However, the following side effects have been observed:

Uncommon Side Effects of Circadin

  • changes in mood such as irritability, restlessness and nervousness
  • headaches and migraine
  • insomnia, unusual dreams and nightmares
  • abdominal pain and indigestion
  • lethargy and tiredness
  • dizziness
  • high blood pressure
  • pain in the extremities
  • mouth ulcers
  • feeling weak
  • changes in the composition of your blood (will show in blood tests)
  • jaundice (yellowing of skin and eyes)
  • inflammation of the skin, dry skin, itchy skin or skin rash
  • sweating at night
  • weight gain
  • changes in your liver function
  • excretion of glucose in the urine
  • menopausal symptoms
  • excess excretion of proteins in the urine

Do not drive or operate machinery if Circadin is making you feel drowsy.

For all known side effects of Circadin, read the patient leaflet supplied with your melatonin tablets.

Drug Interactions

Melatonin tablets can interact with certain other medications, such as:

  • other sleeping tablets and sedatives
  • warfarin
  • beta-blockers and some other blood pressure medications
  • alcohol
  • NSAIDs e.g. ibuprofen
  • oestrogens (for example the contraceptive pill and medications used for hormone replacement therapy)
  • fluvoxamine (used to treat psychiatric conditions)
  • psoralens (used to treat certain skin conditions)
  • cimetidine
  • quinolones
  • rifampicin
  • imipramine (for the treatment of depression)
  • the epilepsy medication carbamazepine
  • thioridazine (used to treat schizophrenia)
  • certain anti-depressants
  • adrenergic agonists/antagonists (used to treat a range of conditions, including high blood pressure and nasal congestion)
  • opiate agonists/antagonists (used to treat drug addiction)
  • prostaglandin inhibitors (including non-steroidal anti-inflammatories)
  • tryptophan
  • Benzodiazepines and non-benzodiazepine hypnotics

Do not take melatonin tablets if you are allergic to melatonin or any other ingredient in the tablets.

Alcohol and tobacco can reduce the effectiveness of melatonin tablets. Abstain from smoking tobacco and drinking alcohol while taking Circadin.

Tell your doctor if you suffer from:

  • liver or kidney problems
  • an intolerance to certain sugars
  • an autoimmune disease
  • epilepsy

If you have a question about this service, please email [email protected] with the question, and one of our doctors will get back to you within 24 hours.

Trustpilot: What people say about DrEd.com
UK Online Doctor for Circadin

Jet Lag Products

Save Time & Embarrassment

Our fast, convenient service is extremely straightforward
and you don't need to visit a doctor to use it.

Choose your medication

You'll complete a short online health assessment and choose the medication you need. If you're unsure, our in-house GPs can also recommend the best treatment for you.

Our in-house GP prescribes your medication

Our doctors will review your order, issue your prescription and pass it straight to a pharmacist to be dispensed.

Delivered to your door or collect from store

Free First Class delivery is included and next day delivery starts at just £3.99. OR you can collect from any Royal Mail Local Collect® at your convenience.

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Complete Confidentiality

We take precautions that other online providers don't,
so you’re given a convenient and discreet service.

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FREE Fast Delivery

Orders placed before 4pm will be dispatched the same day.

Next Day Click & Collect

Available to Collect: Thursday 25 Feb 2016 after 11am
Get an SMS/email to collect from your preferred Royal Mail location

Standard Delivery

Estimated Delivery: Saturday 27 Feb 2016 - Tuesday 01 Mar 2016

Next Day Express

Estimated Delivery: Friday 26 Feb 2016 by 1pm

Discreet Packaging

All of your medication will be delivered in plain, unlabeled
packaging. A signature will be required but it does not
have to be the patient.

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1,000,000 Customers Treated

DrEd is a brand you can trust. We've treated 1,000,000 patients
since 2011, and are certified by the CQC and MHRA.

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